Our cells become less functional as we age, making us more vulnerable to disease. It was once thought that this process was inevitable, but emerging science has revealed that the aging process can be reversed at the cellular level. We're creating the first medicines that build on these discoveries to restore youthful function in old cells.
Explore the Science
Epigenetic marks on our DNA tell each cell in the body which genes to use. Aging degrades these marks, making our old cells less functional and impairing our health.
Our medicines activate transcription factor genes that reprogram the epigenome to a youthful state.
We know that this is possible, but the combination of factors to restore youth in each cell type is unknown.
Discovering these payloads is the core challenge in our work.
Until recently, it wasn't possible.
Our discovery process starts with our AI system that designs payloads to make old cells look & act young.
We then test thousands of designs simultaneously using genomics and retrain models on our new data iteratively.
Ultimately, we test the most effective payloads for their ability to restore youthful function in old cells and preclinical models.
We're starting by inventing medicines to treat diseases that resemble an accelerated form of the aging that occurs in everyone.
Our initial programs are focused on restoring youthful function in the liver, immune system, and vasculature. If successful, we imagine these medicines could restore youthful metabolism, energy levels, resilience to disease, and even cognition later in life.
